Begrensning av TOCP-indusert oocyttskade ved å etterfylle NMN
Introduksjon
Triocresyl phosphate (TOCP)jegs widely used inthe realm ofindustry and agriculture in the last century. However, itjegssubsequentlybanned due to the increasing understanding of its toxicity. In the 21st century, TOCPcomesback into the limelight somthe aviation industrysprings up. This research uncovers the adverse effects of TOCP on the reproductive system. Notably,nikotinamidmononukleotid (NMN),a crucial intermediate in the generation ofNAD+,may serve as a therapeutic intervention to attenuate theoocyte damage caused by TOCP.
About TOCP
TOCP, a classic aromatic organophosphate ester, generally functions asflame retardant, plasticizer, lubricant, and jet fuel additive due to its chemical and thermal stability. At room temperature, TOCP is an odorless, yellowish transparent liquid. It is insoluble in water, but soluble in organic solvents such as alcohol, ether and benzene. In addition to its use in aviation industry, TOCP is currentlyappliEdin the manufacturing of construction materials such as plastics, furniture, textiles, printed circuit boards, and insulation.
The negative roles of TOCP in oocytes
Through the analyses of germinal vesicle breakdown (GVBD) and polar body extrusion (PBE), it is discovered thatTOCP impedes the maturation process of oocyte meiotic division, suppressing the reinitiation of oocytes and the final extrusion of the first polar body.Remarkably, maturation of oocytes is deemed as acritical prerequisite for successful fertilization and subsequent embryonic development.Besides, it triggers disturbances in the cytoskeleton of oocytes and affects the distribution and functionality of mitochondria. Dessutenexposure to TOCP altersthe genes related to histone modification in oocytes, as manifested by the elevated levels of histone methylation at H3K9me3 and H3K27me3.
The reversing effects of NMN on TOCP in oocytes
Replenishing NMN partially restores the spindle/chromosome structure as well as the attachment of microtubules to centromeres, and stabilizes the distribution of actin filaments, thereby maintaining chromosomal integrity and supporting the nuclear maturation process of oocytes. Meanwhile, NMN is also effective in rescuing mitochondrial dysfunctioninduced by TOCP, which restores membrane potential and ATP levels, reducesexcessive ROS production, preventsDNA damage,and hinders cell apoptosisens vel somepigenetic alterations.
Konklusjon
Nicotinamide mononucleotide maintains cytoskeletal stability and fortifies mitochondrial function to mitigate oocyte damage induced by TOCP, signifying its potential application valuein refining reproductive therapeutic strategies.
Referanse
Meng F, Zhang Y, Du J, et al. Nicotinamide mononucleotide maintains cytoskeletal stability and fortifies mitochondrial function to mitigate oocyte damage induced by Triocresyl phosphate. Ecotoxicol Environ Saf. 2024;275:116264. doi:10.1016/j.ecoenv.2024.116264
BONTAC NMN
BONTACer pioner forNMNindustry and the first manufacturer to launch NMN mass production, with the first whole-enzyme catalysis technology around the world. At present, BONTAC has become the leading enterprise in niche areas of coenzyme products. Our services and products have been highly recognized by global partners. Furthermore, BONTAC has the first national and the only provincial independent coenzyme engineering technology research center in Guangdong, China. The coenzyme products of BOMNTAC are widely used in fields such as nutritional health, biomedicine, medical beauty, daily chemicals and green agriculture.
Ansvarsfraskrivelse
Denne artikkelen er basert på referansen i det akademiske tidsskriftet. Den relevante informasjonen er kun gitt for delings- og læringsformål, og representerer ingen medisinske rådgivningsformål. Hvis det er noen brudd, vennligst kontakt forfatteren for sletting. Synspunktene uttrykt i denne artikkelen representerer ikke posisjonen til BONTAC.
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Under ingen omstendigheter vil BONTAC holdes ansvarlig på noen måte for eventuelle krav, skader, tap, utgifter, kostnader eller forpliktelser overhodet (inkludert, uten begrensning, direkte eller indirekte skader for tap av fortjeneste, driftsavbrudd eller tap av informasjon) som følge eller som oppstår direkte eller indirekte fra din tillit til informasjon og materiale på dette nettstedet.
